Product Description

China H&Z® Sitagliptin is approved by the FDA as an adjunct to diet and exercise to improve glycaemic control in patients with T2DM, either as a monotherapy, or in combination with metformin or a peroxisome proliferatoractivated receptor-γ agonist (for example, thiazolidinediones) when the single agent does not provide adequate glycaemic control.

Product Detail

Our firm promises all consumers from the first-class solutions along with the most satisfying post-sale company. We H&Z® warmly welcome our regular and new clients to join us for OEM China China High Purity 99% Sitagliptin Powder CAS 486460-32-6, In case you are on the lookout for a high quality, quick delivery, very best after support and great value supplier in China for long-term small business connection, we'll be your best choice. OEM China China Sitagliptin, Sitagliptin Phosphat Powder, If you give us a list of products you are interested in, along with makes and models, we can send you quotations. Please email us directly. Our goal is to establish long-term and mutually profitable business relationships with domestic and overseas clients. We look forward to receiving your reply soon.

China H&Z® Sitagliptin Factory

 

Sitagliptin CAS:486460-32-6

Sitagliptin phosphate monohydrate CAS: 654671-77-9


Sitagliptin Chemical Properties

MF:C16H15F6N5O

MW:407.31

Melting point:114.1-115.7°C

Boiling point:529.9±60.0°C(Predicted)

Density:1.61±0.1 g/cm3(Predicted)


Sitagliptin Specification:

Items

Standards

Analytical results

Appearance

White to off-whitecrystal powder

white crystal powder

Identification

HPLC RT

Conform

IR

Conform

PHOSPHATE

Conform

Water

3.3~3.7%

3.41%

Residue on ignition

≤0.2%

0.02%

Chiral impurity

≤0.5%

0.01%

Related impurity

Any individual impurity≤0.1%

0.01%

Total impurities≤0.5%

0.02%

HPLC assay

98%-102.0%

100.2%

 

Residual solvents

Acetonitrile≤410ppm

ND

IPAC≤5000ppm

ND

Methanol≤3000ppm

ND

Isopropanol≤5000ppm

1051ppm

 

PSD

95%-100% particle pass through 90 micron seive

Conform

60%-80% particle pass through 63 micron seive

Conform

Conclusion

Conforms withUSP41standard.

 

Sitagliptin Introduction:

H&Z® Sitagliptin is an orally-bioavailable selective DPP4 inhibitor that was discovered through the optimization of a class ofβ-aminoacid-derived DPP4 inhibitors.

It lowers DPP4 activity in a sustained manner following once daily administration, preserves the circulating levels of intact GIP and GLP1 following meals in both acute and chronic studies and reduces blood glucose levels without significant increases in hypoglycaemia.


Sitagliptin Advantage and application:

Clinical studies have shown that cetagliptin is an effective oral drug with good market prospects. It has significant hypoglycemic effects when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated and has few adverse reactions




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