Sitagliptin

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Product Description

China H&Z® Sitagliptin is approved by the FDA as an adjunct to diet and exercise to improve glycaemic control in patients with T2DM, either as a monotherapy, or in combination with metformin or a peroxisome proliferatoractivated receptor-γ agonist (for example, thiazolidinediones) when the single agent does not provide adequate glycaemic control.

Product Detail

Our firm promises all consumers from the first-class solutions along with the most satisfying post-sale company. We H&Z® warmly welcome our regular and new clients to join us for OEM China China High Purity 99% Sitagliptin Powder CAS 486460-32-6, In case you are on the lookout for a high quality, quick delivery, very best after support and great value supplier in China for long-term small business connection, we'll be your best choice. OEM China China Sitagliptin, Sitagliptin Phosphat Powder, If you give us a list of products you are interested in, along with makes and models, we can send you quotations. Please email us directly. Our goal is to establish long-term and mutually profitable business relationships with domestic and overseas clients. We look forward to receiving your reply soon.

China H&Z® Sitagliptin Factory

Sitagliptin CAS:486460-32-6

Sitagliptin phosphate monohydrate CAS: 654671-77-9

Sitagliptin Chemical Properties

MF:C16H15F6N5O

MW:407.31

Melting point:114.1-115.7°C

Boiling point:529.9±60.0°C(Predicted)

Density:1.61±0.1 g/cm3(Predicted)

Sitagliptin Specification:

Items	Standards	Analytical results
Appearance	White to off-whitecrystal powder	white crystal powder
Identification	HPLC RT	Conform
	IR	Conform
	PHOSPHATE	Conform
Water	3.3~3.7%	3.41%
Residue on ignition	≤0.2%	0.02%
Chiral impurity	≤0.5%	0.01%
Related impurity	Any individual impurity≤0.1%	0.01%
Related impurity	Total impurities≤0.5%	0.02%
HPLC assay	98%-102.0%	100.2%
Residual solvents	Acetonitrile≤410ppm	ND
	IPAC≤5000ppm	ND
	Methanol≤3000ppm	ND
	Isopropanol≤5000ppm	1051ppm
PSD	95%-100% particle pass through 90 micron seive	Conform
PSD	60%-80% particle pass through 63 micron seive	Conform
Conclusion	Conforms withUSP41standard.

Sitagliptin Introduction:

H&Z® Sitagliptin is an orally-bioavailable selective DPP4 inhibitor that was discovered through the optimization of a class ofβ-aminoacid-derived DPP4 inhibitors.

It lowers DPP4 activity in a sustained manner following once daily administration, preserves the circulating levels of intact GIP and GLP1 following meals in both acute and chronic studies and reduces blood glucose levels without significant increases in hypoglycaemia.

Sitagliptin Advantage and application:

Clinical studies have shown that cetagliptin is an effective oral drug with good market prospects. It has significant hypoglycemic effects when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated and has few adverse reactions

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